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Our research begins with the design of synthetic biomaterials that support tissue regeneration whilst having low inflammatory response in the human body. We translate this science through preclinical evaluation, clinical collaboration and first-in-human clinical studies to develop solutions that address real clinical needs.
This bench-to-bedside approach has led to Bioactiv® Matrix, our first commercially available product and a Singapore HSA-approved skin substitute for partial-thickness wounds. Our ongoing research continues to expand the Bioactiv® technology platform into new applications across wound care, bone and vascular tissue repair.
1. Y. C. Teo, A. Abbas, E. J. Park, C. Barbut, J-Y. Guo, D. Goh, J. P. S. Yeong, J. W. L. Mok, P. Teo*, 3D Printed Bioactive PLGA Dermal Scaffold for Burn Wound Treatment, ACS Mater. Au, 2023, 3, 265-272. 10.1021/acsmaterialsau.2c00079
2. J. Guo, E. J. Park, A. Abbas, H. T. L. Nguyen, H. Makio, D. Goh, Z-W. Neo, J. P-S. Yeong, C-H. Tan, J. Z. Lo, P. Teo*, Bioactive polyethylene-coated nonwovens for wound healing application, Next Mater., 2024, 3, 100088. 10.1016/j.nxmate.2023.100088
3. E. J. Park, J. Guo, Y. C. Teo, P. Teo*, Biomolecule-modified synthetic polymers for wound healing and orthopedic applications, RSC Appl. Polym., 10.1039/D5LP00074B
4. E. J. Park, B. H. Y. Lim (Yap), X. Wang, Q. Z. Poh, C. H. Tan, L. F. Koh, J. E. Common, P. Teo*, Bioactive PLGA polymer nanoparticle loaded gels for atopic dermatitis treatment, Discover Applied Sciences, 2025, 7, 304. 10.1007/s42452-025-06688-w
5. A. Abbas, E. J. Park, J. Guo, Y. C. Teo, P. Teo, Performance of bioresorbable peptide incorporated polymers produced for fused deposition modelling (FDM), Next Mater., 2024, 5, 100223.
6. J. Guo, E. J. Park, Y. C. Teo, A. Abbas, D. Goh, R. A. A. Smith, Y. Nie, H. L. T. Nguyen, J. P. S. Yeong, S. Cool, H. Makio, P. Teo*, Bioactive polyethylene synthesized by ring opening metathesis polymerization for potential orthopaedic applications, Polym. Chem., 2023, 14, 1743-1751. 10.1039/D2PY01545E
7. Y. C. Teo, E. J. Park, J. Guo, A. Abbas, R. A. A. Smith, D. Goh, J. P. S. Yeong, S. Cool, P. Teo*, Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering, ACS Appl. Bio Mater., 2022, 5, 10, 4770.
8. J. Guo, A. Abbas, C. Barbut, E. J. Park, Q. Lim, T. See, L. Liow, B. Zhang, P. Teo*, 3D Printed biohybrid PE/PCL biphasic osteochondral plug for knee cartilage repair, ACS Mater. Au. 10.1021/acsmaterialsau.5c00193
1. P. Teo*, J-Y. Guo, Y. C. Teo, E. J. Park, Bioactive synthetic polymer, bioactive macromolecule and related methods thereof (Bioactive synthetic polymers by Ring Opening Metathesis Polymerization); WO/2022/093106A1, EP4237464, CN116648472, US20230399457, JP(7814384), SG11202303194R.
2. P. Teo*, H. Makio, J-Y. Guo, E. J. Park, Y. C. Teo, Bioactive polyethylene copolymer, polyethylene macromolecule and related methods thereof (Polyethylene-peptide hybrid copolymer for wound healing); WO/2022/093107A1, EP4237465, CN116648471, US20230416468, JP2024501100 (granted), SG11202303196Y (granted).
3. P. Teo*, A. Abbas, A method of producing a bioactive polymer filament, the bioactive polymer filament and printing methods using the same, WO/2023/033730, US20240351263, CN118302289, EP4395976, JP2024535723, SG11202401230U.
4. P. Teo*, A. Abbas, Y. C. Teo, J. Guo, E. J. Park, J. W.L. Mok, A bioactive poly (lactic-co-glycolic acid) (PLGA) material, related printed structure and related methods thereof; WO2024/181920 A1, SG11202505175Q, EP4688013.
5. P. Teo*, E. J. Park, Y.C. Teo, Hyaluronic acid – based synthetic copolymer, material containing said copolymer, and related methods thereof, WO/2023/211384.
6. P. Teo*, E. J. Park, Bioactive synthetic polymeric nanoparticles, related composition, polymers, macromolecules and methods thereof, PCT/SG2024/050474.
7. P. Teo*, A. Abbas, Y. C. Teo, A bioactive poly (lactic-co-glycolic acid) (PLGA) material comprising protrusions, related printed structure and related methods thereof, WO/2025/165300, PCT/SG2025/050061.
8. P. Teo*, A. Abbas, H. C. Fong, A composite structure and related methods thereof, PCT/SG2025/050469.
9. P. Teo*, A. Abbas, J. Guo, H. C. Fong, A bilayer construct and related methods thereof, PCT/SG2026/050350; SG patent 10202501438P.
10. P. Teo*, A. Abbas, J. Guo, E. J. Park, B. Zhang, Bioactive polyethylene for cartilage regeneration, PCT/SG2026/050075.
11. P. Teo*, A. Abbas, L. Liow, Q. Lim, Osteochondral plug, PCT/SG2026/050077.
P. Teo* - Dr. Peili Teo (Ph.D.), Bioactivx Co-Founder
Contact us for:
- Clinical evidence summary
- Product information
- Meeting with the Bioactivx® team
